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“Afternoon diabetes” and nutrient partitioning
Don’t exacerbate afternoon diabetes with afternoon carbs. Skeletal Muscle As discussed previously [at length], insulin sensitivity in skeletal muscle follows a circadian pattern: starts out high in the...
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Pharmaceutical-grade circadian enhancement?
Is it possible to improve the amplitude and resiliency of your circadian rhythms? Is this desirable? Yes and yes, I think. Introducing, the aMUPA mice (Froy et al., 2006). What you need to know...
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Circadian phase: role of diet
Circadian phase advance: going to bed earlier, waking up earlier. Blue blockers at sunset, bright light at sunrise. Flying east. Autumn. Circadian phase delay: staying up late, sleeping in. Flying...
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Entraining Central and Peripheral Circadian Rhythms
“Desynchronization between the central and peripheral clocks by, for instance, altered timing of food intake, can lead to uncoupling of peripheral clocks from the central pacemaker and is, in humans,...
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Meal timing and peripheral circadian clocks
More on why breakfast in the morning, with light onset is important to avoid circadian desynchrony. FOOD is excellent at entraining peripheral circadian clocks: if you restrict animals to one meal per...
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Circadian Disruption Impairs Survival in the Wild
…just read that huge disasters, ranging from Exxon Valdez to Chernobyl, may have been due, in part, to ignorance of basic principles of circadian rhythms. Gravitas. The master circadian clock, or...
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Dark Skies and Light Pollution
The mission of the International Dark-Sky Association is “to preserve and protect the night time environment and our heritage of dark skies through quality outdoor lighting.” They’re all about...
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LIGHT, Leptin, and Environmental Mismatch
For a long time, the melanocortin system was basically thought to control the color of skin and hair. It still does, and many redheads are redheaded due to polymorphisms in one of the melanocortin...
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Sunlight and the circadian rhythms in your skin
SUNLIGHT entrains circadian rhythms. It gives us vitamin D and melanin; it can give us a sunburn, but some evidence suggests that it does NOT cause skin cancer. “lifetime sun exposure appeared to be...
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Dawn PheNOMNOMNOM
Many pre-diabetic, diabetic, and insulin resistant people have used the low carbohydrate diet to successfully manage their blood glucose levels. It just plain works. FACT (P<0.05). However, a...
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Epigenetics & Circadian Biology: Prader-Willi
I came across a recent study on a mouse model of Angelman Syndrome (an epigenetic disorder), and wasn’t surprised to learn there’s a strong circadian component to it. Epigenetics are one of the main...
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Social jet lag
Social jet lag is basically a general term that refers to circadian arrhythmia. Sort of like insulin resistance, it’s rampantly abundant — some have estimated a prevalence of up to 75%! Social jet...
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Vasopressin’ me again
I’ve been following the links between blood pressure modulatory hormones and circadian rhythms for a while now — and while it’s a fascinating overall picture, this nut hasn’t been cracked [yet]. A...
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Dopamine and breakfast
While opining on her latest protein-rich breakfast experiment, Jane Plain mentioned ghrelin as an important mediator of the circadian component (more on this below). T.S. Wiley wrote a lot about the...
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Insulin resistance and obesity
Some people believe insulin resistance (IR) causes obesity, and they are not pleased when I say this is actually a controversial topic in the field… “Bill isn’t toeing the company line. Again.” So I...
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LIGHT timing for circadian entrainment
Basically, this much is pretty obvious now: LIGHT and food in the morning + darkness after sunset = proper circadian entrainment. But the how is pretty cool; LIGHT affects different biochemical...
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Circadian timing with REV-ERB and PERIOD
The circadian proteins Bmal and casein kinase (CK) enhance and degrade Period (PER), respectively, by completely different mechanisms. Both are necessary, but at different times of day… #context Gross...
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Circadian disruption impairs survival in the wild. Again.
We evolved on Earth, with regular 24-hour “circadian” cycles; abandoning them is incompatible with survival. Natural Selection does not look upon this favorably. Natural selection against a circadian...
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Circadian rhythms and cancer: potential mechanisms
Humans are incredible omnivorous beasts that can thrive on a great variety of diets, but crumble if you mess with their sleep. Circadian arrhythmia is thought to be a driving force behind a few types...
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If meat causes cancer…
Disclaimer: I’m meat-cancer agnostic. *IF* meat causes cancer (and I don’t think it does), it happens extremely slowly and only at very high levels of intake: to get statistically significant risk...
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